Biotech Leader & Scientist

Scientist and biotech leader with a proven ability to translate complex synthetic DNA/RNA solutions into high-value commercial opportunities and strategic partnerships.

Experience

Principal Scientist, Research and Innovation & Corporate Development

Telesis Bio

OCT 2021 – JULY 2024

Key contributor to corporate development strategy, identifying and engaging strategic partners for SOLA enzymatic DNA synthesis technology, expanding market opportunities and partnership pipelines.

  • Developed cost and throughput models to articulate SOLA's value proposition, supporting sales, licensing negotiations, and strategic business cases.
  • Proactively engaged potential partners via industry networking and targeted outreach, driving discussions for technology adoption and market expansion.
  • Collaborated with stakeholders to identify and qualify automation partners, enhancing workflow scalability and commercial viability.
  • Developed custom NGS pipelines to validate product specifications around SOLA synthesis fidelity.

Director, Biofoundry Services & Manufacturing

Telesis Bio

JUL 2018 – OCT 2021

Directed Biofoundry Services, delivering customized DNA solutions to clients, expanding service offerings, and supporting sales engagements for BioXp™ system adoption.

  • Expanded Biofoundry Services portfolio, introducing high-value DNA library synthesis offerings and optimizing workflows to enhance customer experience and revenue streams.
  • Served as technical liaison in sales engagements, advising clients on DNA library design, optimizing quoting strategies, and influencing purchasing decisions.
  • Rapidly launched DNA Library Services product line, aligning R&D, manufacturing, and commercial teams to meet aggressive timelines and market demand.
  • Managed technology transfer of DNA synthesis and plasmid verification to GMP contractors, ensuring scalability and regulatory compliance for commercial production.

Senior Scientist

Telesis Bio

JAN 2017 – JUL 2018

Project Manager and scientific subject matter expert for the launch of the first GMP manufacturing facility of synthetic DNA for personalized immunotherapy.

  • Developed a Synthesis Optimization Tool (SOT) to perform codon optimization while minimizing synthesis complexity, leading to the win of SGI-DNA's first GMP customer
  • As Project Manager, led the team through the engineering runs required for our customer's successful IND submission
  • Updated and validated sequence complexity engine, improving BioXp™ build prediction accuracy from ~80 to >95%

Key Projects

SOLA Enzymatic DNA Synthesis

SOLA Enzymatic DNA Synthesis

Led development of cost and throughput models to articulate SOLA's value proposition, supporting sales, licensing negotiations, and strategic business cases.

DNA SynthesisBusiness DevelopmentStrategic Partnerships
DNA Library Services

DNA Library Services

Rapidly launched DNA Library Services product line, aligning R&D, manufacturing, and commercial teams to meet aggressive timelines and market demand.

Product LaunchCross-functional LeadershipCommercial Strategy
Synthesis Optimization Tool (SOT)

Synthesis Optimization Tool (SOT)

Developed a tool to perform codon optimization while minimizing synthesis complexity, leading to the win of SGI-DNA's first GMP customer.

Computational BiologyAlgorithm DevelopmentBusiness Impact

Publications

DNA library construction using Gibson Assembly®

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Steven Thomas, Nathaniel D. Maynard, and John Gill

Nature Methods2015

Next-Gen Shotgun Cloning Using the Gibson Assembly Method

Christine Chen, Steven Thomas, Nathaniel D. Maynard

2015

Nonlytic Viral Spread Enhanced by Autophagy Components

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Sarah W. Bird, Nathaniel D. Maynard, Markus W. Covert, and Karla Kirkegaard

PNAS2014

Neuron-to-Neuron Transmission of α-Synuclein Fibrils Following Axonal Transport

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Eric C. Freundt, Nathaniel D. Maynard, Eileen Clancy, Shyamali Roy, Luc Bousset, Yannick Sourigues, Markus Covert, Ronald Melki, Karla Kirkegaard, and Michel Brahic

Annals of Neurology2012

Competing Metabolic Pathways Control Viral Frameshifting and Host Resistance

View publication

Nathaniel D. Maynard, Derek Macklin, Karla Kirkegaard, and Markus W. Covert

Molecular Systems Biology2011

Skills & Expertise

Laboratory Techniques

Synthetic DNA/RNAGibson AssemblyGoldenGate AssemblyDNA SequencingCRISPR/Cas9NGS Analysis

Computational Skills

PythonAWSRPerlMySQLCLC Genomics WorkbenchMatLab

Leadership

Strategic PartnershipsTeam ManagementProject ManagementCross-functional CollaborationBusiness DevelopmentProcess Optimization

Specialized Expertise

GMP ManufacturingCodon OptimizationSequence Complexity AnalysisBacteriophage TechniquesWorkflow AutomationCost Modeling

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